Banyere PDGFB?
Ihe na-emepụta platetolet (PDGFB) bụ protoin alkaline echekwara na ụmụ irighiri mmiri. Oke moleular dị arọ cytokin. Ọ nwere ike ime ka sel fibronables, mkpụrụ ndụ glamis, mkpụrụ ndụ na - amị amị na mkpụrụ ndụ ndị ọzọ na - agbadata na g0 / g1 frase ịbanye na nkewa na usoro iku ume. Pdgfb platelet na-enweta na 1974 hụrụ anụ ahụ na-ejikọ ya na mkpụrụ anụ ahụ na-eto nke ọma, aha ya na platelet ma na-arụ ọrụ ma rụọ ọrụ, Nwere ike ime ka otu sel cheotaxis ma kwalite ihe omume nke sel. Na mgbakwunye, macrophphages, mkpụrụ ndụ akwara dị lascroblasts, sel sel eyịn, na eriri eriri mmiri ahụ nwekwara ike ịmịpụta ma hapụ pdgf mgbe ahụ mebiri emebi. Mgbe imeju na-emebi, macrophages, platelet, na-agbanye mkpọrọgwụ ọnya afọ, mkpụrụ ndụ mebiri emebi ma rụọ ọrụ nwere ike nzuzo PDGFB. Ịrụ ọrụ na usoro iwu ma ọ bụ nke paracrine. Achịcha PDGFB bụ ihe na - eme ihe na - eme nke 30kD, ma dịkwa microse nke a na porpyptide eriri
Usoro ndu
A na-ahụta na mbụ na platelets, a na-ahapụ PDGF site na platelet na mmalite nke mmerụ ahụ ka ịmalite nrụpụta anụ ahụ. Ọrụ dị ndụ nke PDGF ọkachasị nwere ọtụtụ akụkụ: ọrụ 1.chemotatic. Ọ na - eme ka ọpụpụ nke Macrophages na Filroplasts, ma nwee chevotaxis na neutrophils, mkpụrụ ndụ na - amị amị na fibrophys. 2.Macleccoconstriction. PDGF na-akpata Vasoconfioction ma bụrụ ihe bara uru vasoactive karịa antuthensin nke Abụọ. 3.PR-For Shariland. PDGF nwere ike ime ka mkpụrụ ndụ akwara vaskụọ dị mma, fibroblasts na mkpụrụ ndụ glial. 4.BỌRỌ AKA NA PHOSPPASASASASE NA PROSRAGLINLINAMISMISM. Mgbe pdgf na mkpụrụ ndụ ya na ndị na - anabata ya, ọ nwere ike ịmegharị usoro phosphoonositol na mwepụta nke Arachidonic, ma na - akwalite mmepụta nke prostaglan, pgi2 na pge2. Ọ na-emekwa ka ịmalite ịmịnye ọkpụkpụ ma na-eme ka ọ vassalition ya na ihe antimatelet ya.
Ọrụ Ahụike
Mgbe anụ ahụ mebiri emebi, clot na-akwụsị ọbara ọgbụgba. Platelet, nke na-agbakọ na saịtị ọbara ọgbụgba, na-etolite ihe mgbochi ihe iji gbochie mfu ọbara. N'otu oge ahụ, platelet na-ahapụ ọtụtụ ihe na-eto eto - nke kachasị na-etolite (PDGF) - nke na-akpali uto nke sel ahụ dị n'akụkụ. Mkpụrụ ndụ ndị a na - ejikọ bụ ndị a na - eme nchọpụta nke iwughachi anụ ahụ mebiri emebi ma na-agwọ ọnya. Nnwale ahụ na-egosi na Pdgf bụ otu n'ime ihe itolite na-etolite ọnya na ọnya na-arụ ọrụ dị mkpa na usoro nke ọnya ọnya, tumadi n'ịkwalite ọnya ọnya. "PDGF bụ ụdị nke na-eto eto protein endogenous, na usoro ọnya na-agwọ ọrịa, site na ụdị sel dị iche iche, gụnyere ụdị BB nwere ike ịkwalite uto Nke fibroblast, yabụ na-akwalite mmegide ọnya na-eme ka ọ dị mma na cell proolifation, na-eme ka iguzogide ọnya ahụ ma belata oge ịgwọ ọrịa.
Nintedanib intermediates
Contact Now